Glycans and the Immune System: Understanding Immune Regulation with Prof. Salomé Pinho

Glycans have a great capacity to fine-tune the inflammatory response and often determine how successfully the immune system distinguishes between friend and foe. While cancer cells build a glycan shield to hide from immune surveillance, pathogens can mimic our glycans in order to evade immune detection and perpetuate infection. Salomé Pinho is the Immunology, Cancer and GlycoMedicine Group leader at the Institute for Research and Innovation in Health at the University of Porto, her research focuses on cancer and inflammatory conditions. Listen in as she introduces us to the intricacies of immune regulation and the potential of glycans as diagnostic and prognostic biomarkers as well as immunotherapeutic targets. 

We Discuss: 

• The role of glycans in immunological tolerance [4:51] 
• Why has glycobiology been neglected for so long? [10:28]
• Cancer and immune tolerance [12:08] 
• Glycans as cancer biomarkers and immunotherapeutic targets [20:00] 
• Glycan mimicry in autoimmune diseases [23:48] 
• Glycans as biomarkers of inflammatory bowel disease (IBD) [27:49] 
• GlycanSwitch Project [35:33] 

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Please be advised that this show is for information only and should not be considered as a replacement or equal to medical advice.